Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.38 |
| ▸ | IL2 | P60568 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800574 | 0.99 | MAP3K11 (0.42) | MAP3K11ROCK1CYP3A4MAP3K7WDR5 | |
| SCHEMBL1799521 | 0.93 | MAP3K11 (0.41) | MAP3K11ROCK1CYP3A4WDR5MAPK8 | |
| SCHEMBL1799160 | 0.92 | HTR2C (0.38) | MAP3K11MAPK8MAPK9MAPK10TNIK | |
| SCHEMBL1801875 | 0.89 | HTR2C (0.48) | ROCK1WDR5MAPK8MAPK9MAPK10 | |
| SCHEMBL1799651 | 0.88 | MAPK8 (0.57) | MAP3K11ROCK1CYP3A4WDR5MAPK8 | |
| SCHEMBL1799652 | 0.88 | MAPK8 (0.57) | MAP3K11ROCK1CYP3A4WDR5MAPK8 | |
| SCHEMBL8176817 | 0.88 | MAPK8 (0.57) | MAP3K11ROCK1CYP3A4WDR5MAPK8 | |
| SCHEMBL1802085 | 0.87 | JAK3 (0.39) | MAP3K11MAPK8MAPK9MAPK10TNIK | |
| SCHEMBL1801553 | 0.84 | MAP3K11 (0.45) | MAP3K11ROCK1CYP3A4MAP3K7WDR5 | |
| SCHEMBL1801418 | 0.83 | MAPK8 (0.47) | ROCK1WDR5MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008095943-A1 | THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |