SCHEMBL8173157

CO[C@H](C[C@H](O)[C@H](COc1ccc(Br)cc1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C

nearest known ligand 0.86

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	BACE1	P56817	19/20	0.86

▸	CTSD	P07339	15/20	0.86

▸	REN	P00797	1/20	0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25916741	0.91	BACE1 (1.00)	BACE1CTSD
SCHEMBL25916740	0.91	BACE1 (1.00)	BACE1CTSD
SCHEMBL8153227	0.84	BACE1 (1.00)	BACE1CTSD
SCHEMBL8151514	0.84	BACE1 (1.00)	BACE1CTSD
SCHEMBL8184478	0.84	BACE1 (0.89)	BACE1CTSDREN
SCHEMBL8165121	0.82	BACE1 (1.00)	BACE1CTSDREN
SCHEMBL8149564	0.82	BACE1 (1.00)	BACE1CTSDREN
SCHEMBL8140774	0.80	BACE1 (0.68)	BACE1CTSDREN
SCHEMBL8174655	0.79	BACE1 (0.78)	BACE1CTSD
SCHEMBL8164193	0.78	BACE1 (0.90)	BACE1CTSDREN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008119773-A1	AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES	MEDIVIR AB (SE)	2008-10-09	—	—	WO	disclosed