Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8187801 | 0.82 | CA12 (0.65) | MEN1KMT2AMAPTCA12CA1 | |
| SCHEMBL13561219 | 0.81 | MEN1 (0.76) | MEN1KMT2AMAPTKCNMA1POLB | |
| SCHEMBL29961069 | 0.80 | MAPT (0.69) | MEN1KMT2AMAPTKCNMA1POLB | |
| SCHEMBL9332891 | 0.79 | MAPT (0.67) | MEN1KMT2AMAPTKCNMA1POLB | |
| SCHEMBL7304335 | 0.78 | HTT (0.72) | MEN1KMT2AMAPTKCNMA1POLB | |
| SCHEMBL8174153 | 0.77 | MEN1 (0.69) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL6477532 | 0.76 | HTT (0.69) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL25306797 | 0.76 | MAPK1 (0.68) | MEN1KMT2AMAPTKCNMA1POLB | |
| SCHEMBL2033537 | 0.76 | MEN1 (0.74) | MEN1KMT2AMAPTKCNMA1POLB | |
| SCHEMBL4254980 | 0.76 | TP53 (0.75) | MEN1KMT2AMAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075044-A | Heterocyclic derivatives as inhibitors of purine salvage phosphoribosyltransferases | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-06-13 | — | — | US | disclosed |