SCHEMBL8174231

SCHEMBL8174231

O=[C]C([C]=O)c1cncc(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.39
CHRNB2 P17787 5/20 0.38
CHRNA4 P43681 5/20 0.38
CHRNB4 P30926 3/20 0.36
CHRNA3 P32297 3/20 0.36
CHRNA1 P02708 1/20 0.34
CHRNA7 P36544 1/20 0.34
MKNK1 Q9BUB5 1/20 0.33
MKNK2 Q9HBH9 1/20 0.33
CYP19A1 P11511 1/20 0.31
P2RX7 Q99572 1/20 0.30
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17431764 0.75 TSHR (0.42)
SCHEMBL9258016 0.73 HCAR2 (0.40) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL7656821 0.72 HCAR2 (0.34) HCAR2CHRNB2CHRNA4CYP11B1CYP11B2
SCHEMBL5700554 0.71 HCAR2 (0.39) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL28097110 0.71 HCAR2 (0.39) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL28044800 0.71
SCHEMBL8447350 0.69 HCAR2 (0.38) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL8444722 0.69 HCAR2 (0.38) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
Water SCHEMBL28044696 0.69 HCAR2 (0.48) HCAR2CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL10405132 0.68 ACP3 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6066646-A INSECTICIDAL, ACARICIDAL OR NEMATICIDAL COMPOSITION ZENECA LIMITED (GB) 2000-05-23 US disclosed
EP-0944625-A1 8-AZABICYCLO 3.2.1]OCTANE-, 8-AZABICYCLO 3.2.1]OCT-6-ENE-, 9-AZABICYCLO 3.3.1]NONANE-, 9-AZA-3-OXABICYCLO 3.3.1]NONANE-, 9-AZA-3-THIABICYCLO 3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES ZENECA LIMITED (GB) 1999-09-29 EP disclosed
WO-1998022462-A1 8-AZABICYCLO[3.2.1]OCTANE-, 8-AZABICYCLO[3.2.1]OCT-6-ENE-, 9-AZABICYCLO[3.3.1]NONANE-, 9-AZA-3-OXABICYCLO[3.3.1]NONANE-, 9-AZA-3-THIABICYCLO[3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES ZENECA LIMITED (GB) 1998-05-28 WO disclosed