Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 2/20 | 0.37 |
| ▸ | RARB | P10826 | 2/20 | 0.37 |
| ▸ | RARG | P13631 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1683989 | 0.92 | RARB (0.45) | EGFRTDP1SMN1; SMN2LMNAMAPT | |
| SCHEMBL2941525 | 0.92 | RARB (0.45) | EGFRTDP1SMN1; SMN2LMNAMAPT | |
| SCHEMBL8175733 | 0.89 | TDP1 (0.43) | TDP1SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL8169474 | 0.86 | EGFR (0.43) | EGFRTDP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8175917 | 0.84 | TDP1 (0.43) | EGFRTDP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1683959 | 0.81 | RARB (0.48) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL1683960 | 0.81 | RARB (0.48) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL8174596 | 0.80 | EGFR (0.41) | EGFRTDP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8175984 | 0.80 | EGFR (0.43) | EGFRTDP1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8167327 | 0.79 | TDP1 (0.46) | EGFRTDP1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150413-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-11-21 | — | — | US | disclosed |