Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 6/20 | 0.53 |
| ▸ | TACR1 | P25103 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 9/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL632868 | 0.92 | TACR3 (0.55) | TACR3TACR1MEN1KMT2ACCR2 | |
| SCHEMBL632869 | 0.92 | TACR3 (0.55) | TACR3TACR1MEN1KMT2ACCR2 | |
| SCHEMBL631934 | 0.87 | TACR3 (0.58) | TACR3TACR1MEN1KMT2ACCR2 | |
| SCHEMBL631631 | 0.87 | TACR3 (0.58) | TACR3TACR1MEN1KMT2ACCR2 | |
| SCHEMBL631238 | 0.86 | TACR3 (0.62) | TACR3TACR1CCR2 | |
| SCHEMBL632029 | 0.85 | TACR3 (0.52) | TACR3TACR1CCR2CCR5 | |
| SCHEMBL632030 | 0.85 | TACR3 (0.52) | TACR3TACR1CCR2CCR5 | |
| SCHEMBL631383 | 0.85 | TACR3 (0.66) | TACR3TACR1MEN1KMT2ACCR2 | |
| SCHEMBL631382 | 0.85 | TACR3 (0.66) | TACR3TACR1MEN1KMT2ACCR2 | |
| SCHEMBL5009009 | 0.84 | TACR3 (0.50) | TACR3TACR1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008081012-A1 | SPIROPIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | WO | disclosed |