Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GPR4 | P46093 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178234 | 1.00 | HPGD (0.39) | HPGDUSP2ALDH1A1KDM4EMAPT | |
| SCHEMBL8179170 | 0.91 | HPGD (0.48) | HPGDUSP2ALDH1A1KDM4EGAA | |
| SCHEMBL8179176 | 0.91 | HPGD (0.48) | HPGDUSP2ALDH1A1KDM4EGAA | |
| SCHEMBL8133352 | 0.90 | HPGD (0.50) | HPGDUSP2ALDH1A1GAARAB9A | |
| SCHEMBL8177970 | 0.90 | HPGD (0.50) | HPGDUSP2ALDH1A1GAARAB9A | |
| SCHEMBL8162792 | 0.88 | TP53 (0.41) | HPGDUSP2ALDH1A1KDM4EPOLB | |
| SCHEMBL8162796 | 0.88 | TP53 (0.41) | HPGDUSP2ALDH1A1KDM4EPOLB | |
| SCHEMBL8183762 | 0.77 | TP53 (0.41) | HPGDALDH1A1KDM4EMAPTGAA | |
| SCHEMBL8183771 | 0.77 | TP53 (0.41) | HPGDALDH1A1KDM4EMAPTGAA | |
| SCHEMBL8187846 | 0.77 | MEN1 (0.34) | HPGDUSP2ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124306-A | Thioalkyl alpha substituted pyrimidine compounds | PHARMACIA & UPJOHN COMPANY (US) | 2000-09-26 | — | — | US | disclosed |