Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 8/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2753133 | 0.86 | PDPK1 (0.42) | BRD4PTPN11HTR6PDPK1POLB | |
| SCHEMBL2752162 | 0.83 | BRD4 (0.36) | BRD4PTPN11HTR6PDPK1POLB | |
| SCHEMBL1799609 | 0.83 | BRD4 (0.37) | BRD4PTPN11HTR6PDPK1POLB | |
| SCHEMBL2754038 | 0.83 | BRD4 (0.35) | BRD4PTPN11HTR6PDPK1POLB | |
| SCHEMBL4555856 | 0.82 | BRD4 (0.36) | BRD4PTPN11HTR6PDPK1POLB | |
| SCHEMBL1801618 | 0.81 | BRD4 (0.46) | BRD4PTPN11IKBKETBK1SUV39H2 | |
| SCHEMBL1801394 | 0.81 | BRD4 (0.35) | BRD4PTPN11HTR6POLBIKBKE | |
| SCHEMBL2752379 | 0.81 | PIK3CA (0.45) | BRD4PTPN11HTR6IKBKETBK1 | |
| SCHEMBL8184787 | 0.80 | POLB (0.36) | BRD4PTPN11HTR6POLBCCNC | |
| SCHEMBL8178143 | 0.78 | BRD4 (0.37) | BRD4PTPN11HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008095944-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |