Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817280 | 0.79 | TSHR (0.48) | TSHRNAAAKDM4EPOLBCA1 | |
| SCHEMBL19600798 | 0.79 | TSHR (0.48) | TSHRNAAAKDM4EPOLBCA1 | |
| SCHEMBL6211257 | 0.79 | TSHR (0.48) | TSHRNAAAKDM4EPOLBCA1 | |
| SCHEMBL6210209 | 0.79 | TSHR (0.48) | TSHRNAAAKDM4EPOLBCA1 | |
| SCHEMBL906396 | 0.78 | TSHR (0.52) | TSHRKDM4EPOLBIDO1HTT | |
| Hydrochloric Acid SCHEMBL3665901 | 0.76 | TSHR (0.50) | TSHRNAAAKDM4EPOLBIDO1 | |
| SCHEMBL22266190 | 0.75 | TSHR (0.48) | TSHRNAAAKDM4EPOLBHTT | |
| SCHEMBL12127745 | 0.75 | GRIN1 (0.66) | TSHRGRIN1GRIN2BSMN1; SMN2KDM1A | |
| SCHEMBL1342676 | 0.75 | GRIN1 (0.66) | TSHRGRIN1GRIN2BSMN1; SMN2KDM1A | |
| SCHEMBL1342673 | 0.75 | GRIN1 (0.66) | TSHRGRIN1GRIN2BSMN1; SMN2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090804-A | PSYCHOLOGICAL DISORDERS; SCHIZOPHRENIA THERAPY | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-18 | — | — | US | disclosed |
| EP-0921123-A1 | NOVEL THIOPHENE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1999-06-09 | — | — | EP | disclosed |