Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.35 |
| ▸ | MERTK | Q12866 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8170677 | 1.00 | AXL (0.35) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL10271900 | 1.00 | AXL (0.35) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL10271513 | 1.00 | AXL (0.35) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL3018666 | 0.92 | AVPR1B (0.39) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL3027277 | 0.92 | AVPR1B (0.39) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL3027272 | 0.92 | AVPR1B (0.39) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL3018676 | 0.92 | AVPR1B (0.39) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL10272053 | 0.92 | PARP1 (0.38) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL8193271 | 0.92 | PARP1 (0.38) | AXLFLT3TYRO3MERTKMAP4K4 | |
| SCHEMBL8176962 | 0.91 | SCN9A (0.38) | AVPR1BSLC2A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |