Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28430815 | 0.74 | TLR8 (0.42) | TLR8KMT2A | |
| SCHEMBL7507515 | 0.71 | LTK (0.30) | — | |
| SCHEMBL23214426 | 0.66 | GRM2 (0.35) | NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4685541 | 0.64 | TDP1 (0.41) | MAPTTLR8PTGS1PTGS2MGLL | |
| SCHEMBL925383 | 0.63 | BRD4 (0.35) | — | |
| SCHEMBL25849475 | 0.62 | MAPT (0.47) | CNR2MAPTNPC1RAB9APTGS1 | |
| SCHEMBL23122711 | 0.62 | CNR2 (0.44) | CNR2MAPTTLR8NPC1RAB9A | |
| SCHEMBL8993091 | 0.61 | EP300 (0.47) | TLR8 | |
| SCHEMBL28383917 | 0.61 | TLR8 (0.62) | MAPTTLR8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23374492 | 0.61 | MAPT (0.46) | CNR2MAPTNPC1RAB9APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159980-A | Pyrazinones and triazinones and their derivatives thereof | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-12-12 | — | — | US | disclosed |