Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185751 | 0.93 | PDE4A (0.49) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8183512 | 0.92 | PDE5A (0.47) | PDE5A | |
| SCHEMBL8183217 | 0.91 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8182511 | 0.91 | PDE4A (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7016377 | 0.91 | PDE5A (0.47) | PDE5A | |
| SCHEMBL8184555 | 0.91 | PDE5A (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8187926 | 0.89 | PDE5A (0.52) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7016974 | 0.87 | PDE5A (0.46) | PDE5A | |
| SCHEMBL8179549 | 0.87 | PDE5A (0.52) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8178467 | 0.86 | PDE5A (0.46) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |