Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015180 | 0.86 | MAOB (0.67) | CYSLTR1GPBAR1CYSLTR2CYP3A4PDE10A | |
| SCHEMBL8179251 | 0.85 | CYSLTR1 (0.52) | CYSLTR1GPBAR1CYSLTR2CYP3A4PDE10A | |
| SCHEMBL8183669 | 0.84 | CYSLTR1 (0.55) | CYSLTR1GPBAR1CYSLTR2PDE10AMAOB | |
| SCHEMBL5777664 | 0.83 | CYSLTR1 (0.69) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL8186447 | 0.83 | CYSLTR1 (0.52) | CYSLTR1GPBAR1CYSLTR2CYP3A4PDE10A | |
| SCHEMBL8187205 | 0.83 | CYSLTR1 (0.57) | CYSLTR1GPBAR1CYSLTR2MAOB | |
| SCHEMBL8180239 | 0.83 | CYSLTR1 (0.51) | CYSLTR1GPBAR1CYSLTR2CYP3A4PDE10A | |
| SCHEMBL8171385 | 0.83 | CYSLTR1 (0.51) | CYSLTR1GPBAR1CYSLTR2PDE10AMAOB | |
| SCHEMBL10663420 | 0.81 | CYSLTR1 (0.52) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL27485722 | 0.81 | CYSLTR1 (0.75) | CYSLTR1GPBAR1CYSLTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643045-B1 | Quinoline derivatives as leukotriene antagonists | NOVARTIS AG (CH) | 2000-03-08 | — | — | EP | disclosed |
| US-5508408-A | LEUKOTRIENE ANTAGONISTS | CIBA-GEIGY CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0643045-A1 | Quinoline derivatives as leukoriene antagonists | CIBA-GEIGY AG (CH) | 1995-03-15 | — | — | EP | disclosed |