Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 17/20 | 0.48 |
| ▸ | TCF7L2 | Q9NQB0 | 17/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181130 | 0.92 | ICAM1 (0.51) | PDE4APDE4BPDE4CPDE4DHRH4 | |
| SCHEMBL8185631 | 0.91 | CTNNB1 (0.49) | HRH4CTNNB1TCF7L2 | |
| SCHEMBL7021735 | 0.90 | HRH4 (0.47) | HRH4CTNNB1TCF7L2 | |
| SCHEMBL8179499 | 0.89 | CTNNB1 (0.50) | PDE4APDE4BPDE4CPDE4DHRH4 | |
| SCHEMBL8182511 | 0.88 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DHRH4 | |
| SCHEMBL8182359 | 0.88 | CTNNB1 (0.53) | PDE4APDE4BPDE4CPDE4DHRH4 | |
| SCHEMBL8186066 | 0.88 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DHRH4 | |
| SCHEMBL8181016 | 0.86 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8185751 | 0.86 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8183463 | 0.86 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |