Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 5/20 | 0.44 |
| ▸ | APP | P05067 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185388 | 0.93 | MEN1 (0.49) | MEN1KMT2AMAPTACHEAPP | |
| SCHEMBL8178577 | 0.93 | PDE5A (0.47) | MEN1KMT2APDE5A | |
| SCHEMBL5124328 | 0.89 | MEN1 (0.52) | MEN1KMT2AMAPTACHEAPP | |
| SCHEMBL8180525 | 0.87 | MEN1 (0.56) | MEN1KMT2AMAPTACHEAPP | |
| SCHEMBL8178327 | 0.86 | MEN1 (0.55) | MEN1KMT2AMAPTACHEAPP | |
| SCHEMBL8184140 | 0.86 | PDE5A (0.47) | MEN1KMT2AALDH1A1PDE5A | |
| SCHEMBL8185246 | 0.86 | MEN1 (0.45) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL8182076 | 0.85 | MEN1 (0.54) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL8179380 | 0.85 | MEN1 (0.54) | MEN1KMT2AACHEAPPALDH1A1 | |
| SCHEMBL8179818 | 0.85 | FYN (0.44) | MEN1KMT2AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |