Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191378 | 0.87 | CYP1A2 (0.80) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL13035437 | 0.87 | CYP1A2 (0.80) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL20579809 | 0.86 | CYP1A2 (0.78) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL8191898 | 0.86 | CYP1A2 (0.78) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL8195308 | 0.84 | CYP1A2 (0.75) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL7499292 | 0.84 | SMN1; SMN2 (0.76) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL5634670 | 0.83 | SMN1; SMN2 (0.59) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL20579845 | 0.81 | CYP1A2 (0.71) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL20579837 | 0.81 | SMN1; SMN2 (0.74) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL10675936 | 0.80 | CYP1A2 (1.00) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| WO-2008082490-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK2, MAP4K2 | CYP1A2 1283/4885CYP2C9 3624/4885CYP2C19 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.