Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | MMP1 | P03956 | 1/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.64 |
| ▸ | MMP13 | P45452 | 1/20 | 0.64 |
| ▸ | MMP14 | P50281 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1421345 | 0.85 | AKR1B1 (1.00) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1421348 | 0.85 | AKR1B1 (1.00) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1421349 | 0.85 | AKR1B1 (1.00) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8183010 | 0.84 | MEN1 (0.76) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL11936898 | 0.83 | AKR1B1 (0.78) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8181494 | 0.82 | MAPT (0.64) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10492259 | 0.80 | MAPT (1.00) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1315178 | 0.80 | MAPT (1.00) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6886335 | 0.79 | MAPT (0.68) | AKR1B1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL8733003 | 0.79 | MAPT (0.65) | AKR1B1MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |