Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 10/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181936 | 1.00 | BRD4 (0.58) | BRD4AKR1B1PIM1PIM2PIM3 | |
| SCHEMBL8001434 | 0.84 | AKR1B1 (0.71) | AKR1B1PIM1PIM2PIM3HPGD | |
| SCHEMBL8001437 | 0.84 | AKR1B1 (0.71) | AKR1B1PIM1PIM2PIM3HPGD | |
| SCHEMBL8172516 | 0.79 | TDP1 (0.68) | BRD4AKR1B1PIM1PIM2PIM3 | |
| SCHEMBL8172521 | 0.79 | TDP1 (0.68) | BRD4AKR1B1PIM1PIM2PIM3 | |
| SCHEMBL8181175 | 0.78 | BRD4 (0.53) | BRD4AKR1B1PIM1PIM2PIM3 | |
| SCHEMBL8185403 | 0.78 | MEN1 (0.71) | AKR1B1PIM1PIM2PIM3HPGD | |
| SCHEMBL8181483 | 0.78 | BRD4 (0.53) | BRD4AKR1B1PIM1PIM2PIM3 | |
| SCHEMBL8181185 | 0.76 | PIM1 (0.55) | BRD4AKR1B1PIM1PIM2PIM3 | |
| SCHEMBL8181583 | 0.73 | PIM1 (0.58) | BRD4PIM1PIM2HPGDMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |