Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950804 | 0.85 | SMN1; SMN2 (0.45) | MAPTLMNASMN1; SMN2KCNA5KDM4E | |
| SCHEMBL10627187 | 0.80 | SMN1; SMN2 (0.47) | MAPTLMNASMN1; SMN2KCNA5SLC6A2 | |
| SCHEMBL3431226 | 0.79 | MAPT (0.46) | MAPTLMNASMN1; SMN2KCNA5SLC6A2 | |
| SCHEMBL22090311 | 0.79 | MAPT (0.50) | MAPTKCNA5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4975876 | 0.78 | MAPT (0.47) | MAPTKCNA5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3048607 | 0.78 | MAPT (0.55) | MAPTLMNAKCNA5SLC6A2SLC6A4 | |
| SCHEMBL29864658 | 0.78 | MAPT (0.55) | MAPTLMNAKCNA5SLC6A2SLC6A4 | |
| SCHEMBL18496129 | 0.78 | MAPT (0.53) | MAPTLMNASMN1; SMN2KCNA5SLC6A2 | |
| SCHEMBL29618691 | 0.78 | MAPT (0.53) | MAPTLMNASMN1; SMN2KCNA5SLC6A2 | |
| SCHEMBL25971609 | 0.77 | SMN1; SMN2 (0.45) | MAPTLMNASMN1; SMN2KCNA5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136810-A | DRUGS AS ENZYME INHIBITORS OF PHOSPHODIESTERASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0885894-A1 | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |