Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870632 | 1.00 | PDE4B (0.58) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL869994 | 0.99 | PDE4B (0.59) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3027701 | 0.99 | PDE4B (0.59) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL870628 | 0.96 | PDE4B (0.52) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3027588 | 0.96 | PDE4B (0.52) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3023564 | 0.95 | PDE4B (0.53) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL870834 | 0.95 | PDE4B (0.53) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL3011833 | 0.92 | PDE4B (0.51) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL871460 | 0.92 | PDE4B (0.51) | PDE4BCYP3A4ACVR1PRKAA2AXL | |
| SCHEMBL870720 | 0.92 | PDE4B (0.51) | PDE4BCYP3A4CYP2C9CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |