Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182496 | 0.95 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| Bicarbonate SCHEMBL7020140 | 0.91 | TDP1 (0.42) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8179770 | 0.90 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8180753 | 0.89 | KDM4E (0.43) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8172194 | 0.88 | FLT1 (0.38) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8185540 | 0.87 | MAPT (0.39) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL8337098 | 0.87 | CSNK2A1 (0.41) | ALDH1A1SMN1; SMN2KDM4ENPSR1PDE5A | |
| SCHEMBL8170200 | 0.86 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| Bicarbonate SCHEMBL7017588 | 0.85 | KDM4E (0.48) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL8171400 | 0.85 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |