Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.70 |
| ▸ | CA9 | Q16790 | 2/20 | 0.70 |
| ▸ | PPARG | P37231 | 1/20 | 0.63 |
| ▸ | PTGES | O14684 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186339 | 1.00 | AKR1B1 (0.70) | AKR1B1PTPN1CA9PPARGPTGES | |
| SCHEMBL15817056 | 0.88 | CA9 (0.78) | AKR1B1PTPN1CA9PPARG | |
| SCHEMBL15817052 | 0.88 | CA9 (0.78) | AKR1B1PTPN1CA9PPARG | |
| SCHEMBL15817054 | 0.88 | CA9 (0.78) | AKR1B1PTPN1CA9PPARG | |
| SCHEMBL17319533 | 0.86 | AKR1B1 (0.84) | AKR1B1PTPN1 | |
| SCHEMBL17319550 | 0.86 | AKR1B1 (0.84) | AKR1B1PTPN1 | |
| SCHEMBL8204542 | 0.83 | AKR1B1 (0.66) | AKR1B1PTPN1CA9PPARG | |
| SCHEMBL8204543 | 0.83 | AKR1B1 (0.66) | AKR1B1PTPN1CA9PPARG | |
| SCHEMBL8188771 | 0.83 | CA9 (1.00) | AKR1B1CA9PPARG | |
| SCHEMBL8188774 | 0.83 | CA9 (1.00) | AKR1B1CA9PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |