Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8176131 | 0.93 | MAPK8 (0.56) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL31090340 | 0.86 | MAPK8 (0.64) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL8186353 | 0.86 | MAPK8 (0.64) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL8186280 | 0.86 | MAPK8 (0.64) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL8176058 | 0.86 | MAPK8 (0.66) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL4789253 | 0.77 | MAPK8 (0.67) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL31090321 | 0.76 | NPC1 (0.65) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL8178294 | 0.76 | MAPK8 (0.61) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL4789242 | 0.76 | MAPK8 (0.68) | MAPK8MAPK9MAPK10ALDH1A1MAPT | |
| SCHEMBL31090329 | 0.75 | MAPK8 (0.67) | MAPK8MAPK9MAPK10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |