Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.55 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 6/20 | 0.51 |
| ▸ | CCND1 | P24385 | 6/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.49 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.49 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2848914 | 0.81 | MAPT (0.55) | PARP10CA1CA2PARP1PARP2 | |
| SCHEMBL8188562 | 0.80 | CDK2 (0.61) | PARP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL15676819 | 0.79 | MAPT (0.56) | PARP10CA1CA2PARP1PARP2 | |
| SCHEMBL8185110 | 0.77 | CCNE2 (0.52) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5372947 | 0.76 | MAP2K4 (0.66) | PARP10CA1CA2PARP1PARP2 | |
| SCHEMBL17279998 | 0.76 | CDK4 (0.50) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7442028 | 0.76 | PARP10 (0.88) | PARP10CA1CA2PARP1PARP2 | |
| SCHEMBL27578364 | 0.75 | BACE1 (0.55) | PARP10CA1CA2PARP1PARP2 | |
| SCHEMBL201761 | 0.74 | PARP10 (1.00) | PARP10CA1CA2PARP1PARP2 | |
| SCHEMBL1692322 | 0.73 | MAPT (0.53) | PARP10CA1CA2PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000046206-A1 | SUBSTITUTED PYRAZOLE BENZYL AMINE DERIVATIVES TO COMBAT ANAEMIAS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-08-10 | — | — | WO | disclosed |