SCHEMBL8189372

SCHEMBL8189372

C(=Cc1ccc(-c2ccc(C=Cc3ccccc3)nc2)cn1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
KDM4E B2RXH2 6/20 0.55
ALDH1A1 P00352 5/20 0.55
HPGD P15428 4/20 0.55
RAB9A P51151 3/20 0.50
LMNA P02545 2/20 0.50
NPC1 O15118 2/20 0.50
PKM P14618 2/20 0.50
GRM4 Q14833 5/20 0.47
HDAC6 Q9UBN7 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP11B1 P15538 1/20 0.47
CYP11B2 P19099 1/20 0.47
MAP4K4 O95819 1/20 0.46
PRKACA P17612 1/20 0.46
CDK8 P49336 1/20 0.46
MAPK14 Q16539 1/20 0.46
LRRK2 Q5S007 1/20 0.46
CLK4 Q9HAZ1 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8189370 1.00 MEN1 (0.61) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL4580523 0.84 MEN1 (0.64) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL4580522 0.84 MEN1 (0.64) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL5053975 0.84 MEN1 (0.62) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL5053974 0.84 MEN1 (0.62) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL5653938 0.83 MEN1 (0.52) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL318211 0.81 MAPT (0.53) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL10517922 0.80 AXL (0.47) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL8175694 0.79 KMT2A (0.58) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL5865297 0.79 CYP19A1 (0.59) MEN1KMT2AKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5872255-A Conjugated organic compounds and preparation process OFFICE NATIONAL D'ETUDES ET DE RECHERCHE AEROSPATIALES (ONERA) (FR) 1999-02-16 US claimed
EP-0834504-A1 Conjugated organic compounds, process for the preparation, materials deriving therefrom, use in electronic, optoelectronic, nonlinear optical and electrooptical devices Office National d'Etudes et de Recherches Aerospatiales "ONERA" (FR) 1998-04-08 EP claimed
US-6051669-A Polymers from certain conjugated organic compounds OFFICE NATIONAL D'ESTUDES ET DE RECHERCHES AEROSPATIALES (ONERA) (FR) 2000-04-18 US disclosed
US-5872255-A Conjugated organic compounds and preparation process OFFICE NATIONAL D'ETUDES ET DE RECHERCHE AEROSPATIALES (ONERA) (FR) 1999-02-16 US disclosed
EP-0834504-A1 Conjugated organic compounds, process for the preparation, materials deriving therefrom, use in electronic, optoelectronic, nonlinear optical and electrooptical devices Office National d'Etudes et de Recherches Aerospatiales "ONERA" (FR) 1998-04-08 EP disclosed