Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL810713 | 0.85 | KDM4E (0.53) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL16044195 | 0.84 | HTT (0.43) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL19674775 | 0.80 | KDM4E (0.47) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL15537150 | 0.80 | KHK (0.44) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL31214295 | 0.80 | KHK (0.62) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL23860817 | 0.80 | KHK (0.62) | KDM4ESMN1; SMN2ALDH1A1GAAKHK | |
| SCHEMBL15568542 | 0.80 | KDM4E (0.42) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2467905 | 0.77 | KDM4E (0.50) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2011637 | 0.77 | KDM4E (0.47) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL21604801 | 0.77 | KDM4E (0.41) | KDM4EHSD17B10SMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6011038-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 2000-01-04 | — | — | US | disclosed |