Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.86 |
| ▸ | REN | P00797 | 3/20 | 0.70 |
| ▸ | CTSD | P07339 | 3/20 | 0.70 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359874 | 1.00 | BACE1 (0.86) | BACE1RENCTSDBACE2 | |
| SCHEMBL2792236 | 1.00 | BACE1 (0.86) | BACE1RENCTSDBACE2 | |
| SCHEMBL2794008 | 0.97 | BACE1 (0.86) | BACE1RENCTSDBACE2 | |
| SCHEMBL2792186 | 0.96 | BACE1 (0.85) | BACE1RENCTSDBACE2 | |
| SCHEMBL2795614 | 0.96 | BACE1 (0.85) | BACE1RENCTSDBACE2 | |
| SCHEMBL2790869 | 0.94 | BACE1 (0.85) | BACE1RENCTSDBACE2 | |
| SCHEMBL2795112 | 0.93 | BACE1 (1.00) | BACE1RENCTSDBACE2 | |
| SCHEMBL8188178 | 0.93 | BACE1 (0.86) | BACE1RENCTSDBACE2 | |
| SCHEMBL2796416 | 0.93 | BACE1 (1.00) | BACE1RENCTSDBACE2 | |
| SCHEMBL2798164 | 0.93 | BACE1 (1.00) | BACE1RENCTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118379-A2 | AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF β-SECRETASE | WYETH (US) | 2008-10-02 | — | — | WO | disclosed |