Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.34 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192315 | 1.00 | CYP2C9 (0.41) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL13035026 | 0.94 | CYP2C9 (0.39) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL13034896 | 0.93 | CYP2C9 (0.41) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL13035246 | 0.92 | CYP2C9 (0.38) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL13034842 | 0.92 | CYP2C9 (0.38) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL8182064 | 0.92 | CYP2C9 (0.41) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL8192086 | 0.92 | CYP2C9 (0.39) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL8192308 | 0.92 | CYP2C9 (0.39) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL8196409 | 0.92 | CYP2C9 (0.39) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 | |
| SCHEMBL8185013 | 0.92 | CYP2C9 (0.42) | CYP2C9CYP2C19CYP2D6ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| WO-2008082490-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK2, MAP4K2 | CYP2C9 3624/4885CYP2C19 3070/4885CYP2D6 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.