SCHEMBL8194576 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	TACR1	P25103	7/20	0.48

▸	SLC6A9	P48067	2/20	0.41

▸	NR1H2	P55055	1/20	0.39

▸	NR1H3	Q13133	1/20	0.39

▸	OPRK1	P41145	1/20	0.39

▸	MTTP	P55157	2/20	0.39

▸	MLYCD	O95822	4/20	0.38

▸	UTS2R	Q9UKP6	1/20	0.38

▸	KLRK1	P26718	1/20	0.38

▸	MICA	Q29983	1/20	0.38

▸	RAET1L	Q5VY80	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1581363	0.90	TACR1 (0.51)	TACR1SLC6A9NR1H2NR1H3OPRK1
SCHEMBL8194590	0.88	TACR1 (0.41)	TACR1SLC6A9
SCHEMBL1581522	0.85	KLRK1 (0.48)	TACR1SLC6A9NR1H2NR1H3UTS2R
SCHEMBL8190210	0.85	UTS2R (0.43)	TACR1SLC6A9UTS2RKLRK1MICA
SCHEMBL1581559	0.85	CHRM5 (0.44)	TACR1SLC6A9
SCHEMBL12720696	0.84	TACR1 (0.44)	TACR1
SCHEMBL1581115	0.83	TACR1 (0.45)	TACR1MTTP
SCHEMBL1581617	0.83	KDM4E (0.49)	TACR1
SCHEMBL1581600	0.83	TACR1 (0.43)	TACR1SLC6A9MLYCDUTS2RKLRK1
SCHEMBL1581525	0.81	PPARA (0.46)	TACR1MTTP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008110488-A1	MALONAMIDES AS OREXIN ANTAGONISTS	F. HOFFMANN-LA ROCHE AG (CH)	2008-09-18	—	—	WO	disclosed