Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 19/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 19/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 17/20 | 0.64 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14175727 | 1.00 | MAPK8 (0.64) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5096394 | 0.90 | MAPK8 (0.62) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5096520 | 0.90 | MAPK8 (0.62) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL3810122 | 0.89 | MAPK8 (0.71) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL8201467 | 0.89 | MAPK8 (0.71) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5102470 | 0.89 | MAPK8 (0.71) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL473588 | 0.85 | MAPK8 (0.68) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5090282 | 0.83 | MAPK8 (0.77) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL3809101 | 0.83 | MAPK8 (0.77) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5096260 | 0.81 | MAPK8 (0.67) | MAPK8MAPK9MAPK10CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008068171-A9 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-07-16 | — | — | WO | disclosed |
| WO-2008068171-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |