Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 4/20 | 0.63 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.63 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.63 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.63 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.63 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30661076 | 0.96 | GRIK1 (0.65) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8190512 | 0.96 | GRIK1 (0.65) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8191679 | 0.92 | GRIK1 (0.73) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8191865 | 0.87 | GRIK1 (0.49) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7802413 | 0.86 | GRIA1 (0.64) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8191795 | 0.85 | GRIK1 (0.60) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8192778 | 0.82 | GRIA1 (0.61) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8181056 | 0.81 | GRIK1 (0.70) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7353360 | 0.81 | GRIK1 (0.59) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8292029 | 0.80 | GRIK1 (0.50) | GRIK1GRIK2GRIK3GRIK4GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067387-C | 1,2,3,4-tetrahydroquinoxalindione derivative | YAMANOUCHI PHARMA CO LTD (JP) | 2001-06-20 | — | — | CN | disclosed |
| US-6096743-A | 1,2,3,4-tetrahydroquinoxalinedione derivative | YAMANOUCHI PHARMACEUTICALS CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| CN-1168670-A | 1,2,3,4-tetrahydroquinoxalindione derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1997-12-24 | — | — | CN | disclosed |
| EP-0784054-A1 | 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-07-16 | — | — | EP | disclosed |