SCHEMBL8196330

SCHEMBL8196330

CCCN(CCC)C(=O)C1=Cc2ccc(OC)cc2N=C(N)C1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 20/20 0.70
TLR7 Q9NYK1 7/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10343253 0.91 TLR8 (0.62) TLR8TLR7
SCHEMBL25345509 0.86 TLR8 (0.60) TLR8TLR7
SCHEMBL1589391 0.86 TLR8 (0.65) TLR8TLR7
SCHEMBL10044370 0.85 TLR8 (0.73) TLR8TLR7
SCHEMBL18041347 0.85 TLR8 (0.72) TLR8TLR7
SCHEMBL19416469 0.84 TLR8 (0.72) TLR8TLR7
SCHEMBL1239780 0.84 TLR8 (0.69) TLR8TLR7
SCHEMBL21841760 0.84 TLR8 (0.76) TLR8TLR7
SCHEMBL7512646 0.83 TLR8 (0.67) TLR8TLR7
SCHEMBL18041368 0.83 TLR8 (1.00) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6043238-A 2-Aminobenzazapine derivatives PFIZER INC. (US) 2000-03-28 US disclosed
EP-0825186-A1 2-Aminobenzazepine derivatives and their use for the treatment of immunosuppression PFIZER INC. (US) 1998-02-25 EP disclosed