Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12821119 | 0.88 | PDE3B (0.54) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| SCHEMBL11398470 | 0.85 | PDE3B (0.73) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| Hydrochloric Acid SCHEMBL11278036 | 0.84 | PDE3B (0.71) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| SCHEMBL2772072 | 0.82 | PDE3B (1.00) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| SCHEMBL10844973 | 0.81 | PDE3B (0.50) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| SCHEMBL10844930 | 0.81 | PDE3B (0.49) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| SCHEMBL10848919 | 0.80 | PDE3B (0.48) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| SCHEMBL10843626 | 0.79 | PDE3B (0.47) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| SCHEMBL10843423 | 0.79 | PDE3B (0.47) | PDE3BPDE3AMEN1PDE2AKMT2A | |
| SCHEMBL10845253 | 0.79 | PDE3B (0.47) | PDE3BPDE3AMEN1PDE2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910597-B2 | platelet lowering agent anagrelide especially 3-and 5-substituted analogues, with reduced potential for cardiovascular side-effects; imidazo[2,1-b]quinazolin-2-one derivatives; by inhibiting megakaryocytopoeisis; antiproliferative agents | SHIRE LLC (US) | 2011-03-22 | — | — | US | disclosed |
| US-20100137343-A1 | SUBSTITUTED QUINAZOLINES | SHIRE LLC (US) | 2010-06-03 | — | — | US | disclosed |
| US-20080176877-A1 | SUBSTITUTED QUINAZOLINES | SHIRE LLC (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080176877-A1 | SUBSTITUTED QUINAZOLINES | SHIRE LLC (US) | 2008-07-24 | — | — | US | disclosed |
| WO-2008065444-A2 | SUBSTITUTED QUINAZOLINES | SHIRE LLC (US) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176877-A1 | SUBSTITUTED QUINAZOLINES | MPL, THPO, ABL1 | PDE3B 232/4885PDE3A 563/4885MEN1 291/4885 |
| US-20100137343-A1 | SUBSTITUTED QUINAZOLINES | MPL, THPO, ABL1 | PDE3B 232/4885PDE3A 563/4885MEN1 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.