Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 19/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 18/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 16/20 | 0.67 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | JUN | P05412 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814504 | 1.00 | MAPK8 (0.67) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5102560 | 1.00 | MAPK8 (0.67) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5093797 | 0.88 | MAPK8 (0.66) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL14175726 | 0.86 | MAPK8 (0.64) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL14175732 | 0.86 | MAPK8 (0.64) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL8195109 | 0.86 | MAPK8 (0.64) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL8197149 | 0.86 | MAPK8 (0.64) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL5102745 | 0.86 | MAPK8 (0.63) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL8195115 | 0.86 | MAPK8 (0.63) | MAPK8MAPK9MAPK10CDK2CCNE1 | |
| SCHEMBL14175723 | 0.86 | MAPK8 (0.63) | MAPK8MAPK9MAPK10CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008068171-A9 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-07-16 | — | — | WO | disclosed |
| WO-2008068171-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS JNK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |