SCHEMBL8197312

SCHEMBL8197312

N#Cc1ccc(-n2[nH]cc(-c3cccnc3)c2=O)nc1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
VHL P40337 4/20 0.67
P4HTM Q9NXG6 9/20 0.65
EGLN1 Q9GZT9 8/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3619693 0.99 VHL (0.65) VHLP4HTMEGLN1
SCHEMBL3590658 0.85 VHL (0.67) VHLP4HTMEGLN1
SCHEMBL3591779 0.82 VHL (0.71) VHLP4HTMEGLN1
SCHEMBL8186022 0.82 VHL (0.71) VHLP4HTMEGLN1
SCHEMBL3592741 0.82 VHL (0.71) VHLP4HTMEGLN1
SCHEMBL3595365 0.82 VHL (0.71) VHLP4HTMEGLN1
Hydrochloric Acid SCHEMBL3617381 0.81 VHL (0.70) VHLP4HTMEGLN1
SCHEMBL3597407 0.80 VHL (1.00) VHLP4HTMEGLN1
SCHEMBL3599948 0.80 P4HTM (0.72) VHLP4HTMEGLN1
SCHEMBL3613910 0.80 VHL (1.00) VHLP4HTMEGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097404-B1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER IP GMBH (DE) 2016-07-27 EP disclosed
WO-2008067874-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-06-12 WO disclosed