Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.68 |
| ▸ | RELA | Q04206 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | F2 | P00734 | 1/20 | 0.65 |
| ▸ | PLG | P00747 | 1/20 | 0.65 |
| ▸ | PLAU | P00749 | 1/20 | 0.65 |
| ▸ | PLAT | P00750 | 1/20 | 0.65 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.65 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.63 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.63 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.62 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431209 | 0.94 | MELK (0.76) | MELKNPC1TP53GAANFKB1 | |
| SCHEMBL4566270 | 0.94 | MELK (0.76) | MELKNPC1TP53GAANFKB1 | |
| SCHEMBL531914 | 0.88 | NPC1 (0.66) | MELKNPC1TP53GAANFKB1 | |
| SCHEMBL24892142 | 0.87 | MELK (0.87) | MELKNPC1TP53NFKB1RAB9A | |
| SCHEMBL28778476 | 0.86 | MELK (0.90) | MELKNPC1TP53GAANFKB1 | |
| SCHEMBL14863153 | 0.86 | PLAU (0.61) | MELKNPC1TP53GAANFKB1 | |
| Hydrochloric Acid SCHEMBL28778457 | 0.85 | MELK (0.88) | MELKNPC1TP53NFKB1HTT | |
| Hydrochloric Acid SCHEMBL8550787 | 0.85 | PLAU (0.60) | MELKNPC1RAB9AF2PLG | |
| SCHEMBL3658561 | 0.84 | F2 (0.57) | MELKF2PLGPLAUPLAT | |
| Hydrochloric Acid SCHEMBL1188323 | 0.83 | NPC1 (0.65) | MELKNPC1TP53RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110934-A | Substituted benzamide derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-08-29 | — | — | US | disclosed |
| CN-1222145-A | Substituted benzamide derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM PLC (GB) | 1999-07-07 | — | — | CN | disclosed |
| EP-0906283-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997048683-A1 | SUBSTITUTED BENZAMIDE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1997-12-24 | — | — | WO | disclosed |