Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.67 |
| ▸ | FLT1 | P17948 | 14/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.67 |
| ▸ | KIT | P10721 | 10/20 | 0.61 |
| ▸ | CSF1R | P07333 | 2/20 | 0.61 |
| ▸ | FLT4 | P35916 | 2/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | HLA-A | P04439 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.58 |
| ▸ | FRK | P42685 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.58 |
| ▸ | STK3 | Q13188 | 1/20 | 0.58 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.58 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.58 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.58 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6609613 | 0.99 | KDR (0.65) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL8205457 | 0.90 | KDR (0.73) | KDRFLT1PDGFRBKITCSF1R | |
| Hydrochloric Acid SCHEMBL6607476 | 0.89 | KDR (0.72) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL8205892 | 0.89 | KDR (0.59) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL6607263 | 0.89 | KDR (0.73) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL8205919 | 0.89 | KDR (0.62) | KDRFLT1PDGFRBKIT | |
| Hydrochloric Acid SCHEMBL6606778 | 0.88 | KDR (0.58) | KDRFLT1PDGFRBKITCSF1R | |
| Hydrochloric Acid SCHEMBL6609409 | 0.88 | KDR (0.61) | KDRFLT1PDGFRBKIT | |
| SCHEMBL8198715 | 0.87 | KDR (0.73) | KDRFLT1PDGFRBKIT | |
| SCHEMBL8209289 | 0.86 | KDR (0.70) | KDRFLT1PDGFRBKITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970070-A1 | PHTHALAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | Novartis AG (CH) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998035958-A1 | PHTHALAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | NOVARTIS AG (CH) | 1998-08-20 | — | — | WO | disclosed |