SCHEMBL8200263

SCHEMBL8200263

c1ccc(CCCCc2ccncc2)cc1

nearest known ligand 0.81

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.61
CYP1A2 P05177 3/20 0.61
CYP3A4 P08684 3/20 0.61
CYP2D6 P10635 3/20 0.61
CYP2C9 P11712 3/20 0.61
CYP2C19 P33261 3/20 0.61
HIF1A Q16665 1/20 0.61
MAOA P21397 1/20 0.56
MAOB P27338 2/20 0.54
LOXL2 Q9Y4K0 1/20 0.52
SIGMAR1 Q99720 1/20 0.52
HRH3 Q9Y5N1 1/20 0.52
LTA4H P09960 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9588693 0.98 HRH1 (0.65) HRH1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9587455 0.98 HRH1 (0.65) HRH1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL12040597 0.98 HRH1 (0.65) HRH1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL123539 0.95 CYP1A2 (0.61) HRH1CYP1A2CYP3A4CYP2D6CYP2C9
Iodide SCHEMBL8083284 0.93 CYP1A2 (0.59) HRH1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL27346649 0.93 CYP1A2 (0.59) HRH1CYP1A2CYP3A4CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL6419195 0.93 CYP1A2 (0.59) HRH1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9114210 0.90 CYP1A2 (0.65) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL726645 0.89 HRH1 (0.73) HRH1CYP1A2CYP3A4CYP2D6CYP2C9
Bromide SCHEMBL10614809 0.87 CYP1A2 (0.63) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117702142-A C (C) 4 Process for preparing substituted pyridine derivatives 五邑大学 2024-03-15 CN disclosed
US-6043227-A C11 carbamates of macrolide antibacterials PFIZER INC. (US) 2000-03-28 US disclosed
US-5262420-A Phenylalkylpyridines IDEMITSU KOSAN CO., LTD. (JP) 1993-11-16 US disclosed
US-4136180-A HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS PFIZER INC. (US) 1979-01-23 US disclosed
US-4062960-A Hypolipidemic alkenesulfonamides PFIZER INC. (US) 1977-12-13 US disclosed
US-3983107-A ARTERIOSCLEROSIS PFIZER INC. (US) 1976-09-28 US disclosed