Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203360 | 0.87 | GSK3B (0.33) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL8906722 | 0.80 | KDM4E (0.36) | POLBTOP2ATOP2B | |
| SCHEMBL8134319 | 0.80 | KDM4E (0.40) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL8200875 | 0.75 | GSK3B (0.33) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9232358 | 0.71 | KDM4E (0.40) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9234627 | 0.71 | CACNA1F (0.51) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9235745 | 0.71 | KDM4E (0.46) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL6213897 | 0.71 | GSK3B (0.49) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9233837 | 0.69 | KDM4E (0.54) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9234604 | 0.69 | KCNH2 (0.41) | GSK3BCACNA1FPOLBMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682030-B1 | 8-Amino-10(azabicycloalkyl)-pyrido[1,2,3-d,e] [1,3,4] benzoxadiazine derivatives, process for their preparation and antibacterial agents containing them | BAYER AG (DE) | 2000-07-05 | — | — | EP | disclosed |
| EP-0683169-A1 | 8-Amino-pyrido 1,2,3-de 1,3,4 benzoxadiazine derivatives, and antibacterial agents containing them | BAYER AG (DE) | 1995-11-22 | — | — | EP | disclosed |
| EP-0682030-A1 | 8-Amino-10(azabicycloalkyl)-pyrido[1,2,3-d,e] [1,3,4] benzoxadiazine derivatives, process for their preparation and antibacterial agents containing them | BAYER AG (DE) | 1995-11-15 | — | — | EP | disclosed |