Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8221068 | 0.99 | MAPT (0.47) | MAPTTP53SMN1; SMN2THRBLMNA | |
| SCHEMBL8221080 | 0.89 | MAPT (0.54) | MAPTTP53SMN1; SMN2THRBLMNA | |
| SCHEMBL8218244 | 0.89 | MAPT (0.45) | MAPTTP53SMN1; SMN2THRBLMNA | |
| Hydrochloric Acid SCHEMBL8218987 | 0.89 | MAPT (0.53) | MAPTTP53SMN1; SMN2THRBLMNA | |
| SCHEMBL8221093 | 0.88 | MAPT (0.44) | MAPTTP53SMN1; SMN2THRBLMNA | |
| Hydrochloric Acid SCHEMBL8222018 | 0.88 | MAPT (0.44) | MAPTTP53SMN1; SMN2THRBLMNA | |
| SCHEMBL8201867 | 0.88 | MAPT (0.63) | MAPTSMN1; SMN2LMNAKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL8220303 | 0.87 | MAPT (0.43) | MAPTTP53SMN1; SMN2THRBLMNA | |
| Hydrochloric Acid SCHEMBL8215501 | 0.87 | MAPT (0.62) | MAPTSMN1; SMN2LMNAKDM4ENPC1 | |
| SCHEMBL8209221 | 0.86 | MAOB (0.52) | MAPTTP53SMN1; SMN2THRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008023-A1 | CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | claimed |
| WO-2000008023-A1 | CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | disclosed |