Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.78 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 15/20 | 0.63 |
| ▸ | TOP2A | P11388 | 2/20 | 0.57 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10679561 | 0.92 | CACNA1F (0.78) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL12665464 | 0.91 | KCNH2 (0.74) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9522715 | 0.91 | CACNA1F (0.76) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL12831520 | 0.91 | MEN1 (0.78) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10123852 | 0.89 | CACNA1F (0.74) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10108762 | 0.89 | CACNA1F (0.74) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL10701879 | 0.89 | POLB (0.71) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9147650 | 0.89 | CACNA1F (0.79) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL2739184 | 0.88 | CACNA1F (0.73) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| Sparfloxacin SCHEMBL1387460 | 0.88 | KCNH2 (1.00) | CACNA1FPOLBMAPK1CACNA1DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008097546-A2 | COMPOUNDS THAT INHIBIT CHOLINESTERASE | COLUCID PHARMACEUTICALS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |