Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | RET | P07949 | 6/20 | 0.36 |
| ▸ | ROS1 | P08922 | 6/20 | 0.36 |
| ▸ | FLT3 | P36888 | 6/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984275 | 1.00 | CHUK (0.40) | CHUKPIM2MAPK8MAPK9RET | |
| SCHEMBL1984278 | 1.00 | CHUK (0.40) | CHUKPIM2MAPK8MAPK9RET | |
| SCHEMBL1984281 | 1.00 | CHUK (0.40) | CHUKPIM2MAPK8MAPK9RET | |
| SCHEMBL1984570 | 0.87 | MAPK8 (0.40) | MAPK8MAPK9ALDH1A1 | |
| SCHEMBL1984567 | 0.87 | MAPK8 (0.40) | MAPK8MAPK9ALDH1A1 | |
| SCHEMBL1984569 | 0.87 | MAPK8 (0.40) | MAPK8MAPK9ALDH1A1 | |
| SCHEMBL395555 | 0.86 | PIK3CA (0.39) | RETROS1FLT3AXLMERTK | |
| SCHEMBL395556 | 0.86 | PIK3CA (0.39) | RETROS1FLT3AXLMERTK | |
| SCHEMBL8210412 | 0.85 | CHUK (0.37) | CHUKMAPK8MAPK9RETROS1 | |
| SCHEMBL13406842 | 0.85 | CHUK (0.37) | CHUKMAPK8MAPK9RETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032162-A1 | PYRIDO (2, 3-D) PYRIMIDIN0NE COMPOUNDS AND THEIR USE AS PI3 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-03-20 | — | — | WO | disclosed |