Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 13/20 | 0.60 |
| ▸ | TP53 | P04637 | 11/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321536 | 0.90 | MDM2 (0.58) | MDM2TP53PGRMAOB | |
| SCHEMBL1321531 | 0.90 | MDM2 (0.58) | MDM2TP53PGRMAOB | |
| SCHEMBL1319494 | 0.88 | MDM2 (0.56) | MDM2TP53PGR | |
| SCHEMBL1319498 | 0.88 | MDM2 (0.56) | MDM2TP53PGR | |
| SCHEMBL27875560 | 0.88 | MDM2 (0.65) | MDM2TP53PGRMAOB | |
| SCHEMBL1318951 | 0.87 | MDM2 (0.57) | MDM2TP53PGRMAOB | |
| SCHEMBL1318947 | 0.87 | MDM2 (0.57) | MDM2TP53PGRMAOB | |
| SCHEMBL1321507 | 0.86 | MDM2 (0.59) | MDM2TP53PGR | |
| SCHEMBL1321510 | 0.86 | MDM2 (0.59) | MDM2TP53PGR | |
| SCHEMBL1322523 | 0.86 | MDM2 (0.61) | MDM2TP53PGRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008034736-A2 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-27 | — | — | WO | disclosed |