Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.39 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3625146 | 1.00 | HIF1A (0.47) | HIF1ATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3625149 | 1.00 | HIF1A (0.47) | HIF1ATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5598036 | 0.89 | HIF1A (0.46) | HIF1ATSHRSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL29765456 | 0.87 | HIF1A (0.60) | HIF1ATSHRALDH1A1LMNAPOLB | |
| SCHEMBL3311081 | 0.87 | HIF1A (0.60) | HIF1ATSHRALDH1A1LMNAPOLB | |
| SCHEMBL29765448 | 0.87 | HIF1A (0.60) | HIF1ATSHRALDH1A1LMNAPOLB | |
| SCHEMBL3621124 | 0.87 | HIF1A (0.60) | HIF1ATSHRALDH1A1LMNAPOLB | |
| SCHEMBL5597762 | 0.87 | TSHR (0.48) | HIF1ATSHRSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8613981 | 0.86 | HIF1A (0.53) | HIF1ATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7773929 | 0.86 | HIF1A (0.47) | HIF1ATSHRMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124493-A | Process for the preparation of o-chloromethyl-phenylglyoxylic acid derivatives | NOVARTIS FINANCE CORPORATION (US) | 2000-09-26 | — | — | US | disclosed |
| US-5756811-A | Process for the preparation of o-chloromethyl-phenylglyoxylic acid derivatives | NOVARTIS CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |