Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 13/20 | 0.71 |
| ▸ | PIM1 | P11309 | 2/20 | 0.61 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.61 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203880 | 1.00 | HPGD (0.71) | HPGDPIM1PIM2CISD1HDAC4 | |
| SCHEMBL4762769 | 0.89 | HPGD (0.71) | HPGDPIM1PIM2CISD1PTPN1 | |
| SCHEMBL8203885 | 0.88 | HPGD (0.54) | HPGDPIM1PIM2CISD1HDAC4 | |
| SCHEMBL1299214 | 0.83 | HPGD (1.00) | HPGDPIM1PIM2CISD1PTPN1 | |
| SCHEMBL1299215 | 0.83 | HPGD (1.00) | HPGDPIM1PIM2CISD1PTPN1 | |
| SCHEMBL9311521 | 0.81 | HPGD (0.69) | HPGDPIM1PIM2CISD1PTPN1 | |
| SCHEMBL9311517 | 0.81 | HPGD (0.69) | HPGDPIM1PIM2CISD1PTPN1 | |
| SCHEMBL8196269 | 0.78 | SMN1; SMN2 (0.48) | HPGDHDAC8 | |
| SCHEMBL20642164 | 0.78 | HPGD (0.56) | HPGDPIM1PIM2CISD1POLB | |
| SCHEMBL9312021 | 0.78 | HPGD (0.61) | HPGDPIM1PIM2CISD1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36575-E | Pyridine and thiazolidinedione derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-15 | — | — | US | disclosed |
| EP-0257781-B1 | A METHOD FOR PRODUCING THIAZOLIDINEDIONE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1991-09-18 | — | — | EP | disclosed |
| US-4898947-A | Pyridine and thiazolidinedione derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-02-06 | — | — | US | disclosed |
| US-4812570-A | Method for producing thiazolidinedione derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-03-14 | — | — | US | disclosed |
| EP-0257781-A1 | A method for producing thiazolidinedione derivatives | Takeda Chemical Industries, Ltd. (JP) | 1988-03-02 | — | — | EP | disclosed |