Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | PLD2 | O14939 | 2/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479450 | 0.91 | BACE1 (0.61) | BACE1BACE2KDM4EALDH1A1KDM4C | |
| SCHEMBL3479511 | 0.77 | BACE1 (0.58) | BACE1BACE2MCHR1 | |
| SCHEMBL3479445 | 0.77 | BACE1 (0.58) | BACE1BACE2MCHR1 | |
| SCHEMBL3479443 | 0.77 | BACE1 (0.58) | BACE1BACE2MCHR1 | |
| SCHEMBL2435311 | 0.76 | BACE1 (0.68) | BACE1BACE2 | |
| SCHEMBL13031126 | 0.74 | BACE1 (0.49) | BACE1 | |
| SCHEMBL3479612 | 0.72 | BACE1 (0.53) | BACE1BACE2KDM4EALDH1A1KDM4C | |
| SCHEMBL592530 | 0.71 | BACE1 (0.60) | BACE1BACE2KDM4EALDH1A1KDM4C | |
| SCHEMBL3479509 | 0.71 | BACE1 (0.64) | BACE1 | |
| SCHEMBL3479463 | 0.71 | BACE1 (0.64) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030412-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | disclosed |