Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205013 | 1.00 | MAPT (0.54) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL8205017 | 1.00 | MAPT (0.54) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL8211222 | 0.85 | MAPT (0.73) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL14407429 | 0.85 | MAPT (0.70) | MAPTALDH1A1MAPK1TDP1PDE4B | |
| SCHEMBL1101968 | 0.85 | MAPT (0.73) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL8211219 | 0.85 | MAPT (0.73) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL8211228 | 0.85 | MAPT (0.73) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL6881113 | 0.84 | MAPT (0.77) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL16543009 | 0.79 | MAPT (0.55) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL14213565 | 0.76 | MAPT (0.70) | MAPTALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000032598-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC. (US) | 2000-06-08 | — | — | WO | claimed |
| WO-2000032598-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC. (US) | 2000-06-08 | — | — | WO | disclosed |