Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 2/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211313 | 0.90 | FNTA (0.39) | USP7STK17BSTK17ADRD2FNTA | |
| SCHEMBL13902533 | 0.86 | USP7 (0.37) | USP7DRD2DRD3TP53SMN1; SMN2 | |
| SCHEMBL8193280 | 0.85 | HDAC6 (0.42) | HDAC8HDAC6 | |
| SCHEMBL8203793 | 0.79 | ACVR1 (0.35) | DRD2DRD3GCGRHDAC8HDAC6 | |
| SCHEMBL8206046 | 0.79 | ACVR1 (0.35) | DRD2DRD3GCGRHDAC8HDAC6 | |
| SCHEMBL8206083 | 0.79 | MEN1 (0.35) | DRD2DRD3HTTMAPTHDAC6 | |
| SCHEMBL3920108 | 0.79 | USP7 (0.42) | USP7DRD2DRD3TP53SMN1; SMN2 | |
| SCHEMBL8205988 | 0.79 | ACVR1 (0.43) | — | |
| SCHEMBL8206710 | 0.79 | TMEM97 (0.39) | USP7DRD2DRD3HDAC2HDAC6 | |
| SCHEMBL8206010 | 0.78 | F10 (0.42) | USP7DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052934-A1 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-05-08 | — | — | WO | disclosed |