Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11277126 | 0.83 | POLB (0.52) | SMN1; SMN2MAPTPOLBKMT2AMEN1 | |
| SCHEMBL1115 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL17390148 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPTPOLBKMT2AMEN1 | |
| SCHEMBL1452 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL7847021 | 0.77 | SMN1; SMN2 (0.90) | SMN1; SMN2MAPTKMT2AMEN1NPC1 | |
| SCHEMBL19634985 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTPOLBKMT2AALDH1A1 | |
| SCHEMBL16972520 | 0.76 | SMN1; SMN2 (0.87) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL27312546 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL6362154 | 0.74 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPTKMT2AMEN1NPC1 | |
| SCHEMBL6365491 | 0.73 | SMN1; SMN2 (0.82) | SMN1; SMN2MAPTPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103044331-B | Prepare the new method of the formamide of 3 n-propyl pyrazoles of silaenafil intermediate 4 amino, 1 methyl 5 | 常州市亚邦医药研究所有限公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-103044331-A | Novel method for preparing Sildenafil intermediate 4-amino-1-methyl-3-n-propyl-pyrazole-5-formamide | CHANGZHOU YABANG PHARMACEUTICAL INST CO LTD | 2013-04-17 | — | — | CN | disclosed |
| US-6025499-A | Process for the preparation of a nitropyrazole amide | BAYER AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5969152-A | Process for the preparation of nitropyrazole esters | BAYER AKTIENGESELLSCHAFT (DE) | 1999-10-19 | — | — | US | disclosed |