Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 9/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3493674 | 0.92 | BPTF (0.36) | BPTFBACE1 | |
| SCHEMBL3493671 | 0.92 | BPTF (0.36) | BPTFBACE1 | |
| SCHEMBL3494776 | 0.90 | BACE1 (0.34) | BPTFBACE1 | |
| SCHEMBL3494781 | 0.90 | BACE1 (0.34) | BPTFBACE1 | |
| SCHEMBL3495713 | 0.90 | BACE1 (0.37) | BPTFBACE1 | |
| SCHEMBL3495716 | 0.90 | BACE1 (0.37) | BPTFBACE1 | |
| SCHEMBL16502188 | 0.89 | BACE1 (0.33) | BPTFBACE1 | |
| SCHEMBL3495684 | 0.87 | BACE1 (0.32) | BPTFBACE1 | |
| SCHEMBL3492093 | 0.87 | BACE1 (0.35) | BPTFBACE1GRM2 | |
| SCHEMBL3495688 | 0.87 | BACE1 (0.32) | BPTFBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054698-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-05-08 | — | — | WO | disclosed |